| Date | Location | Result | |
| May 19, 2010 | Spartanburg, S.C. | USC Upstate 8, William & Mary 6 | Box score |
| May 18, 2010 | Spartanburg, S.C. | William & Mary 11, USC Upstate 9 | Box score |
| May 15, 2010 | Spartanburg, S.C. | USC Upstate 12, Kennesaw State 2 | Box score |
| May 15, 2010 | Spartanburg, S.C. | Kennesaw State 10, USC Upstate 6 | Box score |
| May 14, 2010 | Spartanburg, S.C. | USC Upstate 6, Kennesaw State 5 | Box score |
| May 12, 2010 | Spartanburg, S.C. | The Citadel 10, USC Upstate 3 | Box score |
| May 11, 2010 | Mt. Pleasant, S.C. | Coll. of Charleston 20, USC Upstate 3 | Box score |
| May 08, 2010 | DeLand, Fla. | USC Upstate 8, Stetson 7 | Box score |
| May 08, 2010 | DeLand, Fla. | Stetson 19, USC Upstate 7 | Box score |
| May 07, 2010 | DeLand, Fla. | USC Upstate 4, Stetson 2 | Box score |
| Apr 24, 2010 | Macon, Ga. | Mercer 5, USC Upstate 2 | Box score |
| Apr 24, 2010 | Macon, Ga. | USC Upstate 5, Mercer 2 | Box score |
| Apr 23, 2010 | Macon, Ga. | Mercer 8, USC Upstate 6 | Box score |
| Apr 21, 2010 | Clemson, SC | Clemson 22, USC Upstate 4 | Box score |
| Apr 20, 2010 | Columbia, S.C. | South Carolina 4, USC Upstate 2 | Box score |
| Apr 17, 2010 | Spartanburg, S.C. | USC Upstate 4, Campbell 3 | Box score |
| Apr 17, 2010 | Spartanburg, S.C. | Campbell 13, USC Upstate 6 | Box score |
| Apr 16, 2010 | Spartanburg, S.C. | USC Upstate 6, Campbell 5 | Box score |
| Apr 14, 2010 | Asheville, N.C. | USC Upstate 9, UNC Asheville 6 | Box score |
| Apr 13, 2010 | Spartanburg, S.C. | USC Upstate 11, Coll. of Charleston 10 | Box score |
| Apr 11, 2010 | Jacksonville, Fla. | North Florida 10, USC Upstate 0 | Box score |
| Apr 10, 2010 | Jacksonville, Fla. | North Florida 14, USC Upstate 0 | Box score |
| Apr 10, 2010 | Jacksonville, Fla. | North Florida 16, USC Upstate 3 | Box score |
| Apr 07, 2010 | Clinton, S.C. | Presbyterian College 3, USC Upstate 1 | Box score |
| Apr 06, 2010 | Spartanburg, S.C. | Charlotte 10, USC Upstate 8 | Box score |
| Apr 03, 2010 | Spartanburg, S.C. | Jacksonville 10, USC Upstate 9 | Box score |
| Apr 03, 2010 | Spartanburg, S.C. | Jacksonville 10, USC Upstate 8 | Box score |
| Apr 02, 2010 | Spartanburg, S.C. | Jacksonville 16, USC Upstate 3 | Box score |
| Mar 31, 2010 | Charlotte, N.C. | Charlotte 24, USC Upstate 2 | Box score |
| Mar 30, 2010 | Spartanburg, S.C. | USC Upstate 4, UNC Asheville 3 | Box score |
| Mar 27, 2010 | Nashville, Tenn. | USC Upstate 3, Belmont 1 | Box score |
| Mar 27, 2010 | Nashville, Tenn. | Belmont 8, USC Upstate 2 | Box score |
| Mar 26, 2010 | Nashville, Tenn. | Belmont 8, USC Upstate 5 | Box score |
| Mar 24, 2010 | Spartanburg, S.C. | Gardner-Webb 10, USC Upstate 6 | Box score |
| Mar 23, 2010 | Knoxville, Tenn. | Tennessee 9, USC Upstate 1 | Box score |
| Mar 20, 2010 | Johnson City, Tenn. | ETSU 4, USC Upstate 3 | Box score |
| Mar 20, 2010 | Johnson City, Tenn. | ETSU 11, USC Upstate 6 | Box score |
| Mar 19, 2010 | Johnson City, Tenn. | ETSU 13, USC Upstate 4 | Box score |
| Mar 16, 2010 | Spartanburg, S.C. | Charleston Southern 8, USC Upstate 5 | Box score |
| Mar 14, 2010 | Spartanburg, S.C. | Florida Gulf Coast 12, USC Upstate 3 | Box score |
| Mar 13, 2010 | Spartanburg, S.C. | Florida Gulf Coast 10, USC Upstate 9 | Box score |
| Mar 12, 2010 | Spartanburg, S.C. | Florida Gulf Coast 20, USC Upstate 11 | Box score |
| Mar 10, 2010 | Charleston, S.C. | The Citadel 10, USC Upstate 3 | Box score |
| Mar 09, 2010 | Charleston, S.C. | Charleston Southern 8, USC Upstate 4 | Box score |
| Mar 07, 2010 | Spartanburg, S.C. | George Washington 12, USC Upstate 6 | Box score |
| Mar 06, 2010 | Spartanburg, S.C. | George Washington 9, USC Upstate 0 | Box score |
| Mar 05, 2010 | Spartanburg, S.C. | George Washington 5, USC Upstate 1 | Box score |
| Mar 03, 2010 | Spartanburg, S.C. | USC Upstate 9, Gardner-Webb 8 | Box score |
| Feb 28, 2010 | Spartanburg, S.C. | USC Upstate 10, Butler 0 | Box score |
| Feb 28, 2010 | Spartanburg, S.C. | USC Upstate 3, NJIT 2 | Box score |
| Feb 27, 2010 | Spartanburg, S.C. | USC Upstate 8, Dayton 5 | Box score |
| Feb 24, 2010 | Spartanburg, S.C. | USC Upstate 8, Georgia State 5 | Box score |
| Feb 23, 2010 | Panthersville, Ga. | USC Upstate 9, Georgia State 7 | Box score |
| Feb 21, 2010 | Clinton, S.C. | Presbyterian College 3, USC Upstate 2 | Box score |
| Feb 20, 2010 | Spartanburg, S.C. | USC Upstate 6, Presbyterian College 3 | Box score |
| Feb 20, 2010 | Spartanburg, S.C. | Appalachian State 11, USC Upstate 0 | Box score |